Abstract
Birth rate regulation is a major problem of modern medicine. Unfortunately, frequency of artificial abortions is still high not only in developing, but also in developed countries. Abortion results in severe gynecologic and endocrine complications in the woman’s body (Alieva, 2001).Use of intrauterine devices (IUDs) is a most effective method of contraception. A great number of studies in the field of utilization and possible complications of IUDs revealed the occurrence of inflammatory diseases of small pelvis organs (IDSPO).With this in mind, we studied the data obtained from 77 women using copper IUDs in maternity facility №2 of the city of Andizhan (Uzbekistan). Duration of patients’ follow-up ranged 40 days to 6 months. Women did not have contraindications for IUDs according to WHO medical eligibility criteria. Blood was a material for study; it was taken in 40 days, 3 and 6 months following IUD insertion. After insertion of copper IUDs to women, a cytokine cascade was studied in dynamics. The serum content of IL-1, IL-6 and concentration of TNFα was measured in all patients according to the instruction attached to immunoenzymatic analyzer "АТ-858" manufactured in China. The minimum concentration of TNFα reliably identified in this test system made 4 pg/ml.During the study, the women of the test group showed increased proinflammatory cytokines. The further study of vaginal smears confirmed development of bacterial vaginoses in them that suggests a relation of complications due to IUDs with imbalance of the cytokine cascade.Elevated serum concentration of cytokines was revealed in women with IUDs already on the first days of their application.Sharp increase in IL-1 on days 40 and 90 after insertion of IUDs is associated with presence of complications in the form of expulsions and possible development of inflammatory diseases of small pelvis organs.
Highlights
The problem of demand in those or other contraceptives and the frequency of utilization of various methods of contraception to obtain reliable internationally comparable epidemiological data on the use of methods of family planning has not been resolved definitively
An appreciable success has been achieved in the development of new, more perfect contraceptive agents, which are known as a basic method of prevention of abortions and their complications
The women did not have any contraindications for intrauterine devices (IUDs) according to WHO medical eligibility criteria (Medical Eligibility Criteria for Contraceptive Use, 2000)
Summary
The problem of demand in those or other contraceptives and the frequency of utilization of various methods of contraception to obtain reliable internationally comparable epidemiological data on the use of methods of family planning has not been resolved definitively. An objective evaluation of a situation in regions on the use of contraception and a conscious influence on it, is possible only if a unified national reporting system is set up which would enable to receive accurate and continuous information on utilization, availability of various methods of contraception and their demand. Data on the structure of some methods of contraception and their complications can be obtained only from women themselves by means of special studies carried out among them. In model advisory facilities for women these indicators are traditionally developed on the basis of registration form No 30 “Check up chart of dispensary patient,” which is filled up by local doctors, and it is done almost always as a mere formality.
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