Abstract
This article highlights the results of a study of blood parameters in animals with simulated necrotizing ulcerative gingivitis and compares them, under the same conditions, with animals that received local treatment with a developed complex of antioxidant drugs. Following the work tasks, the nature of changes in the state of the antioxidant - prooxidant system and their influence on quantitative and functional indicators of markers of inflammatory intensity was analyzed and investigated during the pathological process in the background and without treatment with a developed complex. This work shows the changes of malonic dialdehyde concentration as an indicator of lipid peroxidation intensity in experimental animals, the level of catalase activity in the blood of animals, and antioxidant-prooxidant balance in the dynamics of necrotizing ulcerative gingivitis.
Highlights
Periodontal disease is a chronic inflammatory process in the periodontal tissues caused by an imbalance between oral biofilms and the patient’s immune response
An in-depth study of the pathogenesis of necrotizing ulcerative gingivitis has indicated an intensification of free radical oxidation reactions of organic structures, which plays a marginal role in expanding the lesion by so-called “secondary alteration” and the persistence of the pathological process
One of the adverse effects of lipid peroxidation (LPO) due to free radical breakdown of polyunsaturated fatty acids is considered the formation of malonic dialdehyde (MDA)
Summary
Periodontal disease is a chronic inflammatory process in the periodontal tissues caused by an imbalance between oral biofilms and the patient’s immune response. In the early progression of periodontal disease, there is a marked oxidative process with increased levels of reactive oxygen and nitrogen species, especially in periodontitis This process can lead to an imbalance in the body response, with concomitant changes in biomolecules, especially lipids, proteins, and nucleic acids, resulting in periodontal tissue damage [8]. Some antioxidant sources found in nature (foods, teas, vitamins, minerals, among others) are currently used in various auxiliary treatments for cardiovascular diseases, pulmonary diseases, aging, and atherosclerosis [10, 11] As most of those somatic diseases have proved physiologic links with periodontal diseases, it was assumed that treatment with antioxidants could lead to a positive result in periodontal diseases. Some literature studies suggest that supplementation with antioxidant components may help to reduce periodontal damage and its systemic effects when compared to the usual treatment [12]
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