Abstract

The main objective of this retrospective study was to evaluate the value of surgical approach in the treatment of children with vesicoureteral reflux (VUR). Material and method: The study was conducted in the period from January 2006 to December 2014, and included children with symptomatic VUR, who were surgically treated. A total of 72 children were treated, of whom 56 were females and 16 were males, aged between 2 and 16 years. They were treated with IV and V grade reflux ureters. Thirty-two of the unilateral refluxes were left-sided, 18 right-sided and 22 both-sided. VUR was diagnosed with Voiding cystourethrography (VCUG). Cohen technique was performed in 64 (90%) patients, Politano-Lead better technique in 4 (5%) patients and Lich-Gregoir technique in 4 (5%) patients. Results: Out of the 72 treated patients, 69 had a postoperative negative finding of VUR on the performed VCUG, indicating a high 95% success rate. In three girls, persistent postoperative reflux was found in postoperative VCUG. In the first patient persistent VUR was unilateral, of V grade. In the second patient, a third-degree VUR was found and the third patient was diagnosed with II grade VUR. Postoperatively, non-febrile UTIs (urinary tract infections) were diagnosed in 23 patients (20 female children and 3 male children) out of 72 patients in total. One female child was hospitalized with febrile UTI and 8 patients or 10% developed febrile UTI within one year of the operative treatment. Conclusion: Open surgery, despite excellent results, is used for more complicated cases, VUR grade IV – V or in previously failed cases, and it does not appear to provide definitive correction of VUR in all patients and does not prevent certain low incidence of UTI postoperatively. Non-febrile UTIs can occur several years after a surgical correction. Endoscopic treatment is an alternative treatment for VUR

Highlights

  • vesicoureteral reflux (VUR) is significant in the siblings of patients with VUR (46%), children with urinary tract infections (UTI) (30%), infants with prenatal diagnosed hydronephrosis (16%) and urogenital abnormalities: posterior urethra valve (PUV) (60%), cloaca (60%), and duplex kidney (46%)[1]

  • The likelihood of spontaneous resolution is inversely proportional to the initial grade of reflux; approximately 80% of low-grade (I and II) reflux will resolve spontaneously vs. about 50% of grade III reflux

  • Spontaneous resolution in primary reflux is about 70%, it is common in children younger than 5 years old and in lower grade of reflux

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Summary

Introduction

VUR is significant in the siblings of patients with VUR (46%), children with urinary tract infections (UTI) (30%), infants with prenatal diagnosed hydronephrosis (16%) and urogenital abnormalities: posterior urethra valve (PUV) (60%), cloaca (60%), and duplex kidney (46%)[1]. Primary VUR may be due to either abnormal position or integrity of the ureterovesical junction (UVJ) (60%), and duplex kidney (46%)[2,3,4].The risk for primary VUR varies based on ethnicity, age and gender. Spontaneous resolution of primary reflux is common. This is thought to be multi-factorial, in part due to remodeling of the UVJ, elongation of the intravesical ureter, and stabilization of bladder voiding dynamics over time. Few or approximately 20% of high-grade (IV and V)[5]

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