Abstract
The defining feature of coronary artery disease is a focal narrowing in the vascular endothelium, which impedes the flow of blood to the myocardium. Atherosclerotic plaque forms the principal lesion, which is composed of a necrotic center containing cell debris, cholesterol, and calcium. Outlining the necrotic center is a fibrous cap made of proliferated smooth muscle cells, connective tissue, and lipids.
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