Abstract
Fibrous dysplasia (FD) is a benign skeletal disease caused by somatic activating mutations of Gs-alpha leading to formation of expansile fibro-osseous lesions. These may occur in isolation or in association with McCune-Albright syndrome (MAS), characterized by skin pigmentation and hyperfunctioning endocrinopathies, including growth hormone (GH) excess. FD in the craniofacial skeleton may result in significant morbidity including facial asymmetry, vision and hearing loss, nasal obstruction, malocclusion, and pain.
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