Abstract
Glucocorticoids have revolutionized the treatment of inflammatory diseases in the past 60 years. The beneficial anti-inflammatory effects are associated with various sideeffects. Osteoporosis resulting in fractures at spine and hips is one of the significant adverse effects with long-term use. Other adverse effects include precipitation of diabetes, hypertension, cataract formation, skin thinning, osteonecrosis and Cushingoid appearance. Around 1% of adult population chronically ingests glucocorticoids on long-term basis and the percentage is higher in the elderly. In one of the largest studies having included more than 250,000 glucocorticoid users and same number of age matched controls, the incidence of hip and vertebral fractures was increased 2–4 fold amongst patients taking daily doses of prednisolone more than 2.5 mg.1 After discontinuation of glucocorticoids, the bone loss is at least partially reversed.2
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