Abstract
Acting via its receptor (PR), progesterone (P4) rapidly induces Indian hedgehog (IHH) in the mouse and thus stimulates endometrial cell proliferation and differentiation via downstream targets (Smo, Ptc-1, Gli1, and Gli2). CDB-2914 (CDB), a selective P4 modulator, binds and occupies both PRA and PRB at higher affinity than P4. Having confirmed differential expression of Ihh in CDB treated human endometrium, our objective was to determine whether Ihh signaling was also affected.
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