Abstract
The yolk/shell nanoparticles exhibiting independent dual-stimuli responsive characteristics show attractable potential as drug delivery system. Unfortunately, their structural effect has not been explored by now. Here, the yolk/shell PMAA/PNIPAM microspheres were prepared under different conditions as the model drug-carriers to investigate the effects of the diameters of the cavity of the middle layers, thicknesses and crosslinking degrees of the PNIPAM shells on the temperature sensitive drug-loading and pH responsive controlled release characteristics, with doxorubicin (DOX) as a model drug. Compared with the core/shell PMAA/PNIPAM microspheres without inner cavity, the yolk/shell PMAA/PNIPAM microspheres possessed higher drug-loading capacity, and the crosslinking degree of the PNIPAM shells is the most determinate factor for the drug-loading and controlled release performance. Such understanding would lead to a better design of excellent smart drug delivery platform.
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