Abstract
Background: People living with HIV (PLWH) are aging worldwide, and different management strategies may be required for older and younger PLWH. However, demographic characteristics, illness distribution, mortality, and independent risk factors in the PLWH population in China are not yet fully understood, especially in patients aged 50 years or older.Methods: We conducted a retrospective analysis of 4445 HIV-positive Chinese inpatients in Chongqing, China.Results: The mortality rate in patients 50 years or older (the older group) was significantly higher than that in those under 50 years (the younger group) (p < 0.001). In the younger group, independent risk factors for death included: nadir CD4+ T-cell counts <200 cells/μL, not owning medical healthcare insurance, not being on cART, injection drug use, and having one of the following comorbidities: Pneumocystis pneumonia, cryptococcal meningitis, AIDS malignancy, non-AIDS malignancy, and kidney disease. In the older group, independent predictors of death included: being urban residents, nadir CD4+ T-cell counts <200 cells/μL, not being on cART, and having comorbidities such as Pneumocystis pneumonia, hepatitis C, talaromycosis, non-AIDS malignancy, and kidney disease.Conclusions: Demographic characteristics, illness distribution, mortality, and independent risk factors for death in HIV-positive patients differ between the older group and the younger group, indicating that a changing suite of medical and allied support services may be required the for management of older PLWH.
Highlights
Since the introduction of combination antiretroviral therapy, the life expectancy of people living with HIV (PLWH) has gradually been approaching that of the general population [1, 2]
After collation of multi-admissions and exclusion of cases with incomplete data and length of hospital stay ≤24 h, 4,445 hospitalized patients with Acquired Immune Deficiency Syndrome (AIDS) were enrolled in this study
We observed that the following factors had significantly increased the risk of death in our hospitalized patients: being aged 50 years or older, being urban residents, nadir CD4+ T-cell counts being
Summary
Since the introduction of combination antiretroviral therapy (cART), the life expectancy of people living with HIV (PLWH) has gradually been approaching that of the general population [1, 2] This improvement in life expectancy and longevity has resulted in an increase in the number of PLWH living into older age, with an estimated 4 million of PLWH being over 50 years old globally. Patients Living With HIV an increasing proportion of new HIV infections in older adults are contributing to this increase in PLWH aged 50 or more [5,6,7] This trend is global, and is observable in both high-income, and low- and middle-income countries (LMIC). Demographic characteristics, illness distribution, mortality, and independent risk factors in the PLWH population in China are not yet fully understood, especially in patients aged 50 years or older
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