Independent respiratory navigators for improved 3D PSIR imaging of myocardial infarctions

Abstract

The distribution of viable and infarcted myocardium is typically visualized using inversion recovery (IR) late gadolinium enhancement (1) or phase-sensitive inversion recovery (PSIR) sequences (2). Transitioning PSIR from breath-hold 2D to respiratory navigator-gated 3D imaging promises higher SNR and CNR, and whole heart coverage (3,4). However, the optimal method for motion compensation with 3D PSIR is undetermined. With standard PSIR, the IR-prepared volume (first heartbeat) is corrected with the phase from the reference volume (second heartbeat), (Fig ​(Fig1a).1a). Current implementations of respiratory navigated 3D PSIR accept data for the reference based solely on navigator NAV1, which takes place over a heartbeat in advance. Respiratory motion occuring between NAV1 and reference volume acquisition, potentially corrupts reference image quality and may compromise the PSIR image. We propose an independently navigated PSIR (INPSIR) sequence with a separate navigator, NAV2, dedicated to motion compensation of the reference volume (Fig ​(Fig1b1b). Figure 1 Schematic of PSIR and INPSIR acquisitions. The second independent navigator provides motion compensation for the phase reference images. Methods Imaging was performed on a 3T system (Philips Healthcare, Best, The Netherlands) using a 32-channel cardiac array coil (InVivo, Gainsville FL). Phantoms: agar gel phantoms with varying T1 values were placed on a pneumatic motor that oscillated 20 mm in the antero-posterior direction every second. Animals: Under ACUC-approved protocol, six swine underwent 2 hr LAD occlusion. Imaging took place 4-25 weeks post-infarction and 10-3 min post double-dose injection of Magnevist (Schering, Germany). A 3D GRE sequence with 1.25x1.25x4 mm3 resolution and 2.5 min scan time ( assuming 100% gating efficiency) was used.