Independent predictors of mortality and 5-year trends in mortality and resource utilization in hospitalized patients with diffuse large B cell lymphoma

Abstract

Background This retrospective study analyzed factors influencing all-cause inpatient mortality in 80,930 adult patients (2016–2020) with diffuse large B cell lymphoma using the National Inpatient Sample database. Methods Utilizing ICD-10 codes, patients were identified, and statistical analysis was conducted using STATA. Fisher’s exact and Student’s t tests compared proportions and variables, multivariate logistic regression examined mortality predictors, and a 5-year longitudinal analysis identified mortality and resource utilization trends. Results The inpatient mortality rate was found to be 6.56% with a mean age of 67.99 years. Several hospital- and patient-level factors including specific comorbidities such as congestive heart failure, atrial fibrillation, acute kidney injury, chronic obstructive pulmonary disease, liver failure, pancytopenia, tumor lysis syndrome, and severe protein-calorie malnutrition were independently associated with inpatient mortality. Hospitalization costs showed an increasing trend, impacting the overall population and survivors. Conclusion These insights may refine risk assessment, treatment selection, and interventions.