Abstract
AbstractPrevious experiments demonstrated that fluorouracil, injected into female mice at day 10 of gestation, reinforced the effects of two limb‐deforming mutant genes, luxoid (lu) and luxate (lx). In the present investigations, male mice heterozygous for lu or lx were mated to + / + females who were injected with fluorouracil at day 11 or 12 of gestation. Some offspring from these matings were mated to + / + mice to determine their genotypes (+ / +, + /lu, or + /lx). Preaxially hyperphalangous hind feet, characteristic of untreated + /lu, and + /lx mice, were found only in the mutation‐bearing offspring. There were no correlations between genotypes and the abnormalities (kinked tail, white belly patch, and small fabella medialis) produced by fluorouracil. It was concluded that under these experimental conditions there were no significant interactions between the teratogen and the mutant genes at 11 and 12 days of development.
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