Abstract
The mammalian evolutionary history of chromosome 13 was characterized and evolutionary-new centromeres compared to two human neocentromeres at 13q21 using chromatin immunoprecipitation and genomic microarrays
Highlights
Evolutionary centromere repositioning and human analphoid neocentromeres occurring in clinical cases are, very likely, two stages of the same phenomenon whose properties still remain substantially obscure
The probes were hybridized on metaphase spreads of 11 primate species, including great apes and representatives of Old World monkey (OWM) and New World monkeys (NWMs)
We found that this chromosome has been exceptionally conserved in evolution and we identified a locus, corresponding to human chromosome band 13q21, where centromere repositioning' (CR) events independently occurred in the OWM and pig lineages, whose ancestors diverged at least 95 million years ago (Mya)
Summary
Evolutionary centromere repositioning and human analphoid neocentromeres occurring in clinical cases are, very likely, two stages of the same phenomenon whose properties still remain substantially obscure. Studies on the evolutionary history of human chromosomes have shown that the centromere can reposition along the chromosome without marker order variation or leading to aneuploidy. This phenomenon is known as 'centromere repositioning' (CR) and has been reported in primates [6,7,8,9,10,11], in non-primate placental mammals [12,13], marsupials [14], birds [15], and plants [16]
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