Abstract
Methods: 361 Han Chinese elderly in Beijing were included. These subjects underwent the following procedures: (1) Personal medical history and physical examination; (2) Routine blood chemistry and urine analysis; (3) Left ventricular mass index was obtained by echocardiography, and ultrasound evaluation of carotid intima-media thickness. We tested the genotypes of six single nucleotide polymorphisms on chromosome 9p21 (rs2383206, rs10965234, rs10965235, rs10757277, rs10811656 and rs1333047). Results: For the SNP rs2383206, Genotypes with allele A (AA/AG) was significantly associated with higher CCA IMT (p=0.003). For the SNP rs1075277, Genotypes with allele A (AA/AG) was significantly associated with higher CCA IMT as well (p=0.021). This phenomenon was not observed in ICA IMT and LVH. After adjustment for age, sex, BMI, SBP, DBP, TC, FPG, general linear regression analysis demonstrated that age (?=0.145, p=0.009) and rs1075277 (?=-0.115, p=0.037) were independently associated with CCA IMT. But there was no association between rs2383206 with CCA IMT. Conclusions: In a cross-sectional study of Han Chinese elderly in Beijing, chromosome 9p21 locus showed a significant association with carotid atherosclerosis, especially CCA IMT. However, there was no association between 9p21and LVH.
Highlights
In 2007, three chip-based Genome-Wide Association Studies (GWAS) simultaneously revealed the significant association between common variants on chromosome 9p21 and Coronary Artery Disease (CAD) [1,2,3]
After adjustment for age, sex, Body Mass Index (BMI), SBP, DBP, TC, FPG, general linear regression analysis demonstrated that age (β=0.145, p=0.009) and rs1075277 (β=-0.115, p=0.037) were independently associated with Common Carotid Arteries (CCAs) Intima-Media Thickness (IMT) (Table 4), there was no association between rs2383206 and CCA IMT
We investigated the relationship between Single Nucleotide Polymorphism (SNP) at chromosome 9p21 among carotid IMT and Left Ventricular Hypertrophy (LVH)
Summary
In 2007, three chip-based Genome-Wide Association Studies (GWAS) simultaneously revealed the significant association between common variants on chromosome 9p21 and Coronary Artery Disease (CAD) [1,2,3]. Only few studies have investigated the association of this newly identified risk 9p21 locus with carotid atherosclerosis and LVH. The six SNPs we choose were placed in two known genes (CDKN2A and CDKN2B), which coded for 3 proteins (p16INK4a, ARF, and p15INK4b) those were expressed at high levels in a wide range of cell types, including endothelial and inflammatory cells. Those cells played important roles in the process of atherosclerosis. We conducted a study using Han Chinese older population resided in Beijing to evaluate the risk of chromosome 9p21 for subclinical atherosclerotic phenotypes, including IMT and LVH
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