Abstract
Interaction of the facilitatory and inhibitory actions of adrenaline on transmitter release was studied in bullfrog sympathetic ganglia. The facilitatory action develops with a slower onset and lasts for a long time even after removal of adrenaline, while the inhibitory action appears with a negligible latency and ceases immediately after removal. The latter is unaffected by the coexistence of the former. Lowering temperature suppresses markedly the facilitation, while it increases the inhibition. These results suggest the lack of interaction of mechanisms for two different actions of adrenaline and the possibility for an involvement of a metabolic process in the mechanism of the facilitatory action.
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