Abstract
This randomized, double-blind, parallel-group study evaluated combination therapy in 31 patients with mild-to-moderate hypertension whose blood pressure levels were not controlled by enalapril, 20 mg/d, monotherapy. Patients were divided into two groups. Group 1 (n = 15) continued enalapril and received indapamide, 2.5 mg/d; group 2 (n = 16) continued enalapril and received hydrochlorothiazide 25 mg/d. After 12 weeks of treatment, both combinations were equally effective in lowering blood pressure; normalized blood pressure levels were seen in 11 patients in each group. Decreases in serum potassium levels and increases in uric acid levels were significant in both groups. Triglyceride blood levels increased significantly more in the hydrochlorothiazide group than in the indapamide group; other metabolic parameters were unaffected by both treatments.
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