Abstract
Toscana virus (TOSV) is an emerging pathogen in the Mediterranean area and is neuroinvasive in its most severe form. Basic knowledge on TOSV biology is limited. We conducted a systematic review on travel-related infections to estimate the TOSV incubation period. We estimated the incubation period at 12.1 days.
Highlights
Toscana virus (TOSV) is an emerging pathogen in the Mediterranean area and is neuroinvasive in its most severe form
An RNA virus, it belongs to the genus Phlebovirus, species (Sandfly fever Naples phlebovirus family Phenuiviridae, order Bunyavirales) (2)
We considered the incubation period (IP) of an infectious disease as the delay between infection and symptom onset; this definition differs from the latent period, which is defined as the time from infection to infectiousness
Summary
Lison Laroche,[1] Frédéric Jourdain,[1] Nazli Ayhan, Anne-Laure Bañuls, Rémi Charrel, Jorian Prudhomme. We conducted a systematic review on travel-related infections to estimate the TOSV incubation period. Jourdain); Aix-Marseille Université, Institut de Recherche pour le Développement, Institut national de la santé et de la recherche médicale, Marseille, France IP estimates are often unsourced, imprecise, and based on limited evidence, as illustrated by the heterogeneous values proposed (Appendix Table 1, https://wwwnc.cdc.gov/EID/article/27/12/203172-App1.pdf) In this context, we conducted a systematic review of symptomatic travel-related neuroinvasive forms of TOSV to provide an evidence-based estimate of the IP. Data related to the duration of travel and the time of symptom onset, gender, age, country in which case was reported, and country of infection were reported. By using Bayesian analysis, we found an IP of 12.1 (95% CI 9.9–14.4) days (data not shown; results same as Figure 2)
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