Abstract
Long non-coding RNAs (lncRNAs) are important participants in human tumors. The current study assessed the clinical value and functional role of TRAF3IP2-AS1 in cervical cancer. Quantitative reverse transcription polymerase chain reaction was used to compare the TRAF3IP2-AS1 levels in serum samples in healthy control, patients with cervical cancer and cervical intraepithelial neoplasia (CIN), as well as in cervical cancer cells. Receiver operator characteristic curve analysis explored the potential diagnostic potential of TRAF3IP2-AS1. Functional and rescue experiments were carried out for analysis of cellular behaviors and miRNA interplays. TRAF3IP2-AS1 was discovered to be downregulated in the serum of cervical cancer patients and could distinguish cervical cancer patients from CIN and healthy individuals. The elevated TRAF3IP2-AS1 expression restrained cell proliferation, migration, and invasion. TRAF3IP2-AS1 could bind with miR-3677-3p to regulate cervical cancer cellular behaviors. TRAF3IP2-AS1 may play a tumor-suppressor role in cervical cancer progression by sponging miR-3677-3p. TRAF3IP2-AS1 appears to have a potential diagnostic value and be a promising treatment target for treating cervical cancer.
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