Increasing to Accuracy Reductions Heterogeneous Dose Distribution to All-Out Volume of the Irradiation at Models Modified Weibull Distribution

Abstract

Purpose: To development of the methods of the estimation quality, systematized clinical information, which is described in the manner of probability of the arising the NTCP (complications in tissues) depending on volume of the irradiation and sharing the dose their uniform and heterogeneous irradiation.
 Material and methods: Used designed mathematical models for calculation of NTCP and mathematical models, which allow to calculate reduction values of the identical doses of the uniform irradiation tissues equivalent on probability of the arising the beam complication to heterogeneous sharing the doses.
 Results: Method of increasing to precision of the estimation to consensus systematized clinical information, founded on its presentation in the manner of differential histogram dose-volume, and on reductions heterogeneous doses distribution in identical dose all-out and uniform irradiation tissue.
 Conclusion: It is shown that designed method of the estimation of the heterogeneous sharing the dose by way of his adduction to equivalent, on probability of the arising the beam complications in tissues, all-out irradiations tissues, allows to raise accuracy of the calculation of the identical dose of the source lumpy distribution tolerants doses. She allows to raise precision of the estimation to consensus systematized clinical values of tolerant doses, received of specialist.