Increasing the aqueous solubility of N-acyl-substituted amino acid esters using iron(II) ions as inhibitors of viral replication in vitro

Abstract

New aromatic and heterocyclic derivatives of N-acylated esters of l-amino acids with aromatic carboxylic acids are proposed as antiviral low molecular weight agents. To increase the aqueous solubility of inhibitors that are insoluble in aqueous solutions, the target compounds were used as iron(II) chloride complexes. It was shown that compounds in the form of coordinated ligands are able to suppress the replication of the strain of influenza A virus resistant to adamantane. The presumed target of inhibitor compounds is viroporin M2 in the envelope of the influenza A virus. At the same time, these compounds were found to be inactive in relation to the SARS-CoV-2 coronavirus strain.