Abstract
Introduction and aimInfective endocarditis (IE) cases are on the rise in the United States. The incidence of IE in patients with inflammatory bowel disease (IBD) has not been reported. Utilizing a national level database, we sought to estimate the incidence of IE in IBD-related hospitalizations and to determine its outcomes. MethodsDischarge records from the National Inpatient Sample were analyzed, and the International Classification of Diseases, ninth revision, Clinical Modification codes (ICD-9-CM) was used to identify adult patients with IBD (Crohn’s disease or ulcerative colitis) and IE between 2003 and 2014. Trends in the incidence of IE were recorded and multivariable regression was used to determine the impact of IE on IBD-hospitalizations.ResultsThe incidence of IE in patients with IBD rose from 14.5 cases per 10,000 admissions in 2003 to 21.7 in 2014. After multivariable adjustment, both patient groups with CD (odds ratio [OR] 3.5, 95% confidence interval [CI] 3.0-4.1) and UC (OR 2.9, 95% CI 2.5-3.5) admitted with IE were found to be at greater risk for in-hospital mortality compared to non-IE admissions. Patients with IBD admitted with IE were found to have greater mean length of stay (13 days vs. six days, p<0.0001) and higher average hospital charges ($36,869.85 vs. $13,324.01, p <0.0001) compared to non-IE admissions. ConclusionsInfective endocarditis is a growing complication in patients with IBD and is associated with increased mortality and utilization of healthcare resources. Further studies addressing the association between IE and IBD are needed.
Highlights
Introduction and aimInfective endocarditis (IE) cases are on the rise in the United States
The incidence of infective endocarditis (IE) in patients with inflammatory bowel disease (IBD) rose from 14.5 cases per 10,000 admissions in 2003 to 21.7 in 2014
Both patient groups with Crohn’s disease (CD) and ulcerative colitis (UC) admitted with IE were found to be at greater risk for inhospital mortality compared to non-IE admissions
Summary
Infective endocarditis (IE) cases are on the rise in the United States. The incidence of IE in patients with inflammatory bowel disease (IBD) has not been reported. Epidemiologic studies reveal that the incidence of infective endocarditis (IE) in the United States is increasing [1]. Between 2000 to 2011, hospital stays attributed to IE have been estimated to have increased by more than half [2]. Such a rise has been attributed to an increase in the number of at-risk populations for developing IE [1, 3,4]. IE represents a significant burden on the healthcare industry with higher rates of mortality and overall hospital costs compared to other hospitalizations [1, 8]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
