Abstract
BackgroundWe aimed to evaluate the incidence of type 1 diabetes mellitus in children <15 years of age (yr) in the Auckland region (New Zealand) over 20 years (1990–2009).MethodsWe performed a retrospective review of all patients <15 yr diagnosed with type 1 diabetes, from an unselected complete regional cohort.ResultsThere were 884 new cases of type 1 diabetes, and age at diagnosis rose from 7.6 yr in 1990/1 to 8.9 yr in 2008/9 (r2 = 0.31, p = 0.009). There was a progressive increase in type 1 diabetes incidence among children <15 yr (p<0.0001), reaching 22.5 per 100,000 in 2009. However, the rise in incidence did not occur evenly among age groups, being 2.5-fold higher in older children (10–14 yr) than in the youngest group (0–4 yr). The incidence of new cases of type 1 diabetes was highest in New Zealand Europeans throughout the study period in all age groups (p<0.0001), but the rate of increase was similar in New Zealand Europeans and Non-Europeans. Type 1 diabetes incidence and average annual increase were similar in both sexes. There was no change in BMI SDS shortly after diagnosis, and no association between BMI SDS and age at diagnosis.ConclusionsThere has been a steady increase in type 1 diabetes incidence among children <15 yr in Auckland over 20 years. Contrary to other studies, age at diagnosis has increased and the greatest rise in incidence occurred in children 10–14 yr. There was little change in BMI SDS in this population, providing no support for the ‘accelerator hypothesis’.
Highlights
The incidence of type 1 diabetes mellitus has been increasing worldwide [1,2,3], and it appears to have been pronounced among children,5 years of age [3,4,5]
There has been a steady increase in type 1 diabetes incidence among children,15 yr in Auckland over 20 years
There was a steady increase in the annual number of newly diagnosed cases of type 1 diabetes in children,15 yr (r2 = 0.80; p,0.0001) of 2.0 additional cases per year, from 23 in 1990/1 to 60 cases per year in 2008/9
Summary
The incidence of type 1 diabetes mellitus has been increasing worldwide [1,2,3], and it appears to have been pronounced among children ,5 years of age (yr) [3,4,5]. This increase has been suggested to be associated with the ‘accelerator hypothesis’ [6]. The incidence of type 1 diabetes in young New Zealanders was assessed as moderate at 17.9 per 100,000 [13]. We aimed to evaluate the incidence of type 1 diabetes mellitus in children ,15 years of age (yr) in the Auckland region (New Zealand) over 20 years (1990–2009)
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
