Abstract
Increasing Human Brain Excitability by Transcranial High- Frequency Random Noise Stimulation
Highlights
Neuroplasticity is an ongoing, self-organizing, adaptive process widespread in cortical areas; it allows the brain to learn and adapt to new environmental situations
short-interval intracortical inhibition (SICI)/intracortical facilitation (ICF) and longinterval intracortical inhibition (LICI) were measured with two different protocols of single- and paired-pulse transcranial magnetic stimulation (TMS) applied in a random order at 0.25 Hz
We demonstrate that weak transcranial random noise stimulation (tRNS) over M1 enhances trode position, intensity, and stimulation duration
Summary
Neuroplasticity is an ongoing, self-organizing, adaptive process widespread in cortical areas; it allows the brain to learn and adapt to new environmental situations. The most well known method currently used to influence excitability of the brain by external means is transcranial magnetic stimulation (TMS) (Barker et al, 1985) It was followed by various repetitive stimulation paradigms, most recently by theta burst stimulation (TBS) (Huang et al, 2005). TBS increased the efficacy of rTMS by reducing stimulus intensity and the number of pulses required to achieve similar aftereffects, its upper safety limits are still unclear due to the potential risk of rTMS inducing seizures (Wassermann, 1998). Another approach, weak transcranial direct current stimulation (tDCS) of the brain has so far avoided this risk. The repeated potentiation of sodium channels has been suggested to be a putative mechanism of tRNS action; its aftereffects may outlast those observed after tDCS stimulation
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