Abstract
Increasing glucose demand increases hepatic pyruvate carboxylase mRNA concentration but not feed intake in late-lactation dairy cows
Highlights
Glucose demand may play an important role in determining the level of feed intake in lactating dairy cattle
Milk production was decreased by phlorizin (24.9 vs 22.8 kg/d; P=0.001), 3.5% fat-corrected milk production was not; phlorizin caused a significant depression in lactose production but not milk fat production
Veenhuizen et al (1988) increased the proportion of propionate used for glucose production by 35% by administering phlorizin at 2 g/d in steers, suggesting that changes in peripheral glucose demand can greatly impact gluconeogenesis
Summary
Glucose demand may play an important role in determining the level of feed intake in lactating dairy cattle. Increasing glucose demand can decrease the molar insulin:glucagon ratio, resulting in enhanced flux through gluconeogenic pathways. This may increase the proportion of propionate that is utilized for glucose production and limit propionate oxidation. If high hepatic ATP concentrations cause the initiation of vagal-mediated satiety signals, decreased propionate oxidation may increase DMI (Allen, 2000).
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