Abstract
The theoretical aspects of solid solutions and eutectic mixtures as well as their application to pharmaceutical systems are discussed. A mechanism is considered by which such solid systems may enhance dissolution rates and, in turn, the gastrointestinal absorption rate and availability of poorly soluble drugs. A degree of ambiguity exists in the literature published to date in this area. This report proposes that results previously attributed to eutectic mixtures are properly explained by the existence of solid solutions. The sulfathiazole–urea and chloramphenicol-urea systems are examined in detail.
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