Abstract
This study investigates the influence of the dietary fibre β-glucan on nutrient composition and mucus permeability.Pigs were fed a standard diet or a diet containing twice the β-glucan content for 3 days (n = 5 per group), followed by the collection of small intestinal mucus and tissue samples. Samples of the consumed diets were subjected to in vitro digestion to determine β-glucan release, nutrient profile and assessment of mucus permeability.In vitro digestion of the diets indicated that 90% of the β-glucan was released in the proximal small intestine. Measurements of intestinal mucus showed a reduction in permeability to 100 nm latex beads and also lipid from the digested enhanced β-glucan diet.The data from this study show for the first time that reducing mass transfer of bile and lipid through the intestinal mucus layer may be one way in which this decrease in bile reabsorption by soluble fibre is enabled.
Highlights
Dietary fibre is an important component in a healthy diet
In addition to demonstrating that the OM10 diet decreased the permeability of the intestinal mucus to 100 nm latex beads, we aimed to show an effect on the diffusion of the digested diet itself
There was an increase in the conjugated secondary bile salt GHDC that is formed as a result of conjugation of Hyodeoxycholic acid (HDCA), which is in turn formed from Deoxycholic acid (DCA) by bacterial enzymes
Summary
Dietary fibre is an important component in a healthy diet. Current knowledge does not explain all the physiological benefits associated with dietary fibre consumption. In the UK most people do not consume the recommended average intake for adults of 18 g (NSP) per day (Scientific Advisory Committee on Nutrition, 2015); the average intake is 12.8 g/day for women and 14.8 g/day for men. This is important because of its association with lowering for cardiovascular disease (CVD). The rate of obesity is increasing in the developed world resulting in increases in morbidity and mortality from CVD and metabolic disorders such as type-2 diabetes. Clinical and epidemiological studies have demonstrated that diet and lifestyle changes are essential parts of a multifaceted approach to prevent and/or limit disease progression
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