Abstract
Copper indomethacin (Cu−Indo) is a nonsteroidal anti-inflammatory drug currently available for veterinary use. Its application is limited to oral formulations because of its poor solubility in biocompatible solvents. In this study, Cu−Indo has been coprecipitated with poly(vinylpyrrolidone) (PVP) to increase the solubility of Cu−Indo in biocompatible solvents. The aerosol solvent extraction system was used to produce Cu−Indo/PVP coprecipitates in various ratios. Carbon dioxide was used as an antisolvent to precipitate PVP and Cu−Indo from dimethylformamide solutions. Microspheres of PVP and Cu−Indo were formed that ranged in size from 50 nm to 4 μm at most conditions studied. A coprecipitate containing 10 wt % Cu−Indo and 90 wt % PVP was found to be at least 93 times more soluble in ethanol than factory-grade Cu−Indo. The significance of these results is that there may now be the potential for Cu−Indo to be used in parenteral applications.
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