Abstract
ABSTRACTAustralia has high and increasing rates of salmonellosis. To date, the serovar distribution and associated antimicrobial resistance (AMR) patterns of nontyphoidal Salmonella enterica (NTS) in Australia have not been assessed. Such information provides critical knowledge about AMR in the food chain and informs decisions about public health. We reviewed longitudinal data on NTS in two Australian states over a 37-year period, between 1979 and 2015, and antimicrobial resistance since 1984. Overall, 17% of isolates were nonsusceptible to at least one antimicrobial, 4.9% were nonsusceptible to ciprofloxacin, and 0.6% were nonsusceptible to cefotaxime. In total, 2.5% of isolates were from invasive infections, with no significant difference in AMR profiles between invasive and noninvasive isolates. Most isolates with clinically relevant AMR profiles were associated with travel, particularly to Southeast Asia, with multiple “incursions” of virulent and resistant clones into Australia. Our findings represent the largest longitudinal surveillance system for NTS in Australia and provide valuable public health knowledge on the trends and distribution of AMR in NTS. Ongoing surveillance is critical to identify local emergence of resistant isolates.
Highlights
IntroductionThe serovar distribution and associated antimicrobial resistance (AMR) patterns of nontyphoidal Salmonella enterica (NTS) in Australia have not been assessed
Australia has high and increasing rates of salmonellosis
Enteritidis isolation was approximately 13:1. This ratio is in marked contrast to observations from Europe and North America, where S
Summary
The serovar distribution and associated antimicrobial resistance (AMR) patterns of nontyphoidal Salmonella enterica (NTS) in Australia have not been assessed Such information provides critical knowledge about AMR in the food chain and informs decisions about public health. Despite high rates of salmonellosis, the trends and prevalence of AMR in NTS in Australia have never been systematically assessed Such information may provide valuable knowledge on the dissemination of AMR in the food chain and allow informed decisions about surveillance requirements and public health interventions. Using longitudinal surveillance data, we describe the serovar distribution, invasive potential, and AMR profiles of NTS isolates from humans in Australia, from the states of Victoria and Tasmania. These data represent the most continuous and systematically collected available data on serotype distribution and AMR in NTS in Australia and highlight the need for comprehensive surveillance of AMR in enteric pathogens
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