Abstract
Sprecher-Goldberger, S. (Inst. Pasteur du Brabant, 28 rue du Remorqueur, 1040 Bruxelles, Belgium), L. Thiry, I. Gould, Y. Fassin and C. Gompel. Increasing antibody titers to herpes simplex virus type 2 during follow-up of women with cervical dysplasia. Amer J Epidemiol 97: 103-110, 1973.-Specific neutralizing antibodies to herpes simplex virus type 2 were titrated in 24 women with cervical dysplasia and in 29 women with inflammatory atypia in cervical smears. The antibody titers were determined 2 to 4 times during a 4 to 13-month period of follow-up, and compared with those of 34 women of the same age with a normal cytological smear. During this period only 13% of the women with dysplasia had no detectable antibodies, none had stable antibodies, and 67% showed a rise in antibody titer. There were antibody variations in the group with normal and atypic smears, but the variations were significantly less frequent than in those with dysplasia. None of 10 hysterectomized women showed an increase in antibody titer. The variations in antibody titer to herpes simplex type 2 virus were not generally paralleled by similar variations in antibody titers to the type 1 virus. These results suggest that the cervix with a cytological diagnosis of dysplasia contains herpes simplex virus antigen(s) since it stimulates the formation of the corresponding antibodies. © 1973 by THE JOHNS HOPKINS UNIVERSITY.
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