Abstract
While hollow fiber bioreactor systems have been used for production of biologicals for almost 25 years, little data are available regarding optimization of these systems. This is due in large part to the lack of a good hollow fiber-specific screening tool. The purpose of this poster is to present recent findings using a novel tool developed specifically for this process: the micro hollow fiber bioreactor. The primary advantage of this tool is that no pumps are required, so that many conditions can be tested simultaneously. This tool has become an integral part of our development screening process, enabling quicker time to production of clinical material at reduced cost (1). Case studies are presented demonstrating the effect of medium and cell line on performance of hollow fiber bioreactors. Additional work demonstrates the value of cell side convection to enhance productivity in the short term and prolong productivity in the long term.
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