Abstract
The effects of systemically administered morphine on the release and metabolism of serotonin (5-HT) in nucleus parafascicularis thalami were evaluated using in vivo microdialysis. The extracellular concentration of 5-HT and its major metabolite 5-hydroxyindoleacetic acid were increased in a dose-dependent manner following the subcutaneous administration of 2.5 and 5 mg/kg morphine sulfate. These results are consistent with findings that the antinociceptive action of morphine is partially mediated through the action of 5-HT within nucleus parafascicularis.
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