Increases in Acute Phase Reactants in a Patient with Scurvy Despite No Inflammation: Review of Literature.

Kaori Kimura,Yasuji Inamo

doi:10.7759/cureus.5608

Abstract

So far, little attention has been paid to the increase in acute phase reactants (APRs) in patients with scurvy. We report that elevated levels of C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and serum amyloid A were shown in a pediatric patient with scurvy despite the absence of inflammation. These peculiar findings are important to discriminate scurvy from other rheumatic diseases.

Highlights

An increase in acute phase reactants (APRs) has not been observed in patients with scurvy
Several reports have described the levels of elevated C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and serum amyloid A, they have not garnered enough attention (Table 1) [1,2,3,4,5,6,7]
CRP does not increase in vitamin D deficiency rickets, which appears in radiological findings as a failure of mineralization in such zones

Summary

Introduction

An increase in acute phase reactants (APRs) has not been observed in patients with scurvy. A 4-year-old male with autism was referred to our hospital because of severe leg pain and gingival bleeding. His laboratory results showed a CRP level of 2.21 mg/dL (reference range

Discussion

Disclosures