Abstract
Background Stroke is the second leading cause of death worldwide. The role of zinc as a new predictor of stroke was considered. Methods This prospective study was conducted in Ayatollah Rouhani Hospital within a year on 100 stroke and 100 control patients. Findings The difference in zinc serum level in two groups was significant (deficiency: 3 (3%) in patients versus 20 (20%) in control group, normal: 25 (25%) versus 54 (54%), and increased level: 72 (72%) versus 26 (26%); p < 0.001). Difference in zinc serum levels was statistically significant with ischemic heart disease (deficiency: 0 cases (0%), normal: 8 cases (24%), increased level: 24 cases (75%), p = 0.003). Increases in zinc serum level were significantly correlated with the frequency of hemorrhagic and ischemic patients (deficiency: 3 (3.3%) hemorrhagic versus 0 (0%) ischemic; normal: 19 (21%) versus 6 (60%), increased level: 68 (75.6%) versus 4 (40%); p = 0.025). Regression logistics showed that ischemic heart disease (p < 0.001; OR = 28.29, %95 CI: 5.53; 144.87), hyperlipidemia (p < 0.001; OR = 0.26, %95 CI: 0.12; 0.56), and zinc serum level (p < 0.001, OR = 15.53, %95 CI: 4.03; 59.83) each had a significant role. Conclusions Babol stroke patients are prone to increased zinc serum level as a new parameter. Ischemic heart disease, increased levels of zinc, and hyperlipidemia were found to be probable predictor factors for stroke in Babol.
Highlights
Stroke is the second leading cause of death worldwide and imposes enormous financial costs on society [1]
Differences in zinc serum levels were significantly correlated with Ischemic heart disease (IHD) as an underlying disease (deficiency: 0 cases (0%), normal: 8 cases (24%), and increased level: 24 cases (75%), p = 0.003)
Increases in zinc serum levels were significantly correlated with increased frequency of hemorrhagic and ischemic patients (deficiency: 3 (3.3%) hemorrhagic versus 0 (0%) ischemic), normal: 19 (21%) versus 6 (60%), increased level: 68 (75.6%) versus 4 (40%), p = 0.025)
Summary
Stroke is the second leading cause of death worldwide and imposes enormous financial costs on society [1]. Studies showed that some trace elements necessary due to their role in maintaining the metabolism of neurons can be considered in the diagnosis and treatment of strokes. The imbalance of these trace elements is correlated with increased risk of a stroke [5]. Many studies have shown that zinc is an independent risk factor for ischemic strokes [11]; both neurotoxic and Stroke Research and Treatment neuron-protective potential of zinc have been reported [5]. Difference in zinc serum levels was statistically significant with ischemic heart disease (deficiency: 0 cases (0%), normal: 8 cases (24%), increased level: 24 cases (75%), p = 0.003). Ischemic heart disease, increased levels of zinc, and hyperlipidemia were found to be probable predictor factors for stroke in Babol
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