Abstract
Dry skin pruritus is common in the elderly. Recent reports show that T-cell signal path is involved in dry skin pruritus. Zeta-chain-associated protein kinase 70 (ZAP70), as a T-cell receptor, may induce interleukin 2 (IL-2) secretion and promote nerve growth factor (NGF) secretion in skin. This study aimed to detect the alteration of ZAP70 in a mice model with dry skin pruritus. The C57BL mice with 5 months and 22 months were used as experimental animal. Following a 5-day period of treatment of back with a mixture of acetone-diethyl-ether-water (AEW), mice exhibited a significant increase in spontaneous scratching behavior directed to the treated back compared to control animals in which back was similarly treated with water only (W). After AEW process, spontaneous scratching in 22-month AEW mice was increased compared to 5-month AEW mice. Western blot and real-time quantitative PCR data analysis showed that ZAP70 expression was significantly increased in 22-month AEW mice compared with 5-month AEW mice. ELISA data showed that secretions of IL-2 and NGF in 22-month AEW mice were higher than 5-month AEW mice. Our results indicate that increased ZAP70 is involved in dry skin in elderly pruritus. Increased secretion of IL-2 and NGF may induce dry skin itch.
Highlights
Itch is one of the most important symptoms in inflammatory skin diseases and allergic disorders
Behavior data analysis in elderly AEW group was significantly increased compared to young AEW group which demonstrates that dry skin pruritus in elderly mice was more serious than in young mice
We find that Zetachain-associated protein kinase 70 (ZAP70) expression in elderly AEW group is statistically increased compared to young AEW group
Summary
Itch is one of the most important symptoms in inflammatory skin diseases and allergic disorders. It is defined as “unpleasant sensation, eliciting the urge to scratch.”. Dry skin is one of the most pruritic skin diseases It is a primary complaint associated with xerosis and other dermatoses that compromise skin barrier integrity, such as atopic dermatitis and psoriasis [1, 2]. As the prevalence of atopy continues to rise, it becomes increasingly important that clinicians understand the mechanisms responsible for itch and, in particular, dry skin itch [4]. The mechanism of dry skin pruritus is poorly understood. Immune response may explain the mechanism of dry skin pruritus
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