Abstract
Repeated inhalation exposures of rats to 900 ppm and 2700 ppm of toluene vapor produced a dose-related increase in drinking behavior and daily water intake with an increase in both the vapor concentration and number of the repeated exposures. A dose-related increase in plasma osmolality and plasma sodium concentration with a concomitant decrease in plasma protein concentration was found in the rats sacrificed 4 hours after cessation of the repeated exposures for 3 weeks to 900 ppm and 2700 ppm of toluene vapor. More positive water balance, increased urine volume, lowered urine osmolality without a significant increase in urinary sodium and potassium excretions occurred on Day 1 following repeated exposures to toluene vapor for 3 weeks. The present blood and urine data indicated that the polydipsia induced by repeated exposure to toluene vapor was related to the increase in both plasma sodium concentration and plasma osmolality.
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