Increased Water Diffusion in the Parcellated Cortical Regions from the Patients with Amnestic Mild Cognitive Impairment and Alzheimer's Disease.

Sung-Han Lin,Yi-Chun Chen,Wen-Chuin Hsu,Shu-Hang Lin,Jur-Shan Cheng,Yao-Liang Chen,Oleksandr Khegai,Chin-Chang Huang,Jiun-Jie Wang

doi:10.3389/fnagi.2016.00325

Abstract

Background: The loss of cortical neuron environment integrity is the hallmark of neurodegeneration diseases such as Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI). To reveal the microenvironment changes in cerebral cortex, the current study aimed to examine the changes of mean diffusivity (MD) in parcellated brain among AD, aMCI patients and normal controls (NC).Methods: Diffusion tensor imaging data with the whole brain coverage were acquired from 28 AD (aged 69.4 ± 8.2 year old), 41 aMCI patients (aged 68.2 ± 6.4 year old) and 40 NC subjects (aged 65.7 ± 6.4 year old). Subsequently, the MD values were parcellated according to the standard automatic anatomic labeling (AAL) template. Only the 90 regions located in the cerebral cortex were used in the final analysis. The mean values of MD from each brain region were extracted and compared among the participant groups. The integrity of the white matter tracts and gray matter atrophy was analyzed using the track-based spatial statistics and voxel-based morphometry approaches, respectively.Results: Significant differences of MD were noticed both in aMCI and AD patients, in terms of the affected regions and the amount of increase. The hippocampus, parahippocampal gyrus and cingulum were the most significantly affected regions in AD patients. From all the 90 cerebral cortex regions, significant increase of MD in the AD patients was found in 40 regions, compared to only one (fusiform gyrus on the right) in aMCI patients. In the disease affected regions, the MD from aMCI patients is in state between NC and AD patients.Conclusions: Increased MD in the specific regions of the brain shows the feasibility of MD as an indicator of the early stage cortical degeneration in aMCI and AD patients.

Highlights

Alzheimer’s disease (AD), a progressive neurodegenerative disease, is the most common form of dementia (Alzheimer’s, 2014)
Among the groups (NC, amnestic mild cognitive impairment (aMCI), and AD), no significant difference was noticed in gender, age and education level (Table 1)
No Apolipoprotein ε4 (ApoE4) carriers were found in normal controls (NC)

Summary

Introduction

Alzheimer’s disease (AD), a progressive neurodegenerative disease, is the most common form of dementia (Alzheimer’s, 2014). In 2014, nearly 44 million population worldwide were affected by Alzheimer’s or related dementia and expected to almost triple in 2050 (Prince et al, 2014). Neuropathological studies showed that patients with AD are often accompanied with the deposition of amyloid and neurofibrillary tangle (NFT), which initiates from the temporal lobe and subsequently spreads out to the whole brain in the later stage (Braak and Braak, 1991). Patients with AD suffer from the loss of brain functions, which typically starts with the impairment of the short-term memory in the early stage and extends to the long-term memory loss. The loss of cortical neuron environment integrity is the hallmark of neurodegeneration diseases such as Alzheimer’s disease (AD) and amnestic mild cognitive impairment (aMCI). To reveal the microenvironment changes in cerebral cortex, the current study aimed to examine the changes of mean diffusivity (MD) in parcellated brain among AD, aMCI patients and normal controls (NC)

Objectives

Methods

Results

Discussion

Conclusion