Abstract

Patients with brushite kidney stones have more severe renal papillary pathology than idiopathic calcium oxalate (CaOx) stone formers (SFs).1 We have shown that papillary tissue from brushite but not CaOx SFs demonstrates abundant neutrophil activation including neutrophil extracellular trap formation, a neutrophil response to bacteria and other perceived pathogens.2 This neutrophil infiltration may explain the increased scarring and inflammation observed in the papillae of brushite SFs.

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