Abstract
This paper considers increased urinary excretion of xanthurenic acid caused by organophosphorous insecticides (OPI's) as a possible biomarker of exposure to OPI's. Urinary xanthurenic acid is assayed by high-performance liquid chromatography. Pyrimidinyl phosphorothioates and crotonamide phosphates are the most potent OPI's, increasing xanthurenic acid urinary excretion up to sixfold. Elevation of xanthurenic acid occurs within 6 hr of OPI administration and persists for 48 hr following a single OPI dose. Age, dietary regimen and several drugs related to OPI action or L-tryptophan metabolism do not affect OPI-increased xanthurenic acid urinary excretion, while its onset and extent is gender-dependent. The magnitude of a single OPI dose for increasing xanthurenic acid excretion (5 mg of diazinon/kg) indicates importance of this phenomenon for occupational and accidental poisonings.
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