Increased Troponin-T level is associated with anthracycline-induced diastolic dysfunction of the left ventricle

Abstract

9722 Background: The serum troponin-T (cTnT) level increases with myocardial damage. We sought to assess whether cTnT level could be a useful marker for the early detection of anthracycline cardiotoxicity. Methods: 41 Patients who had been planned to receive anthracycline containing combination chemotherapy were included into the study. Serum cTnT levels were measured before (baseline) and after first cycle of chemotherapy, and repeated after the last cycle of chemotherapy. In all patients, the left ventricular ejection fraction (LVEF), fractional shortening (FS), early peak flow/atrial flow (E/A) velocity ratio, and the isovolemic relaxation time (IRT) were measured echocardiographically, both before and after the study. Results: LVEF and FS did not change in any patients. In 21 patients (49%), the E/A ratio decreased after therapy. The decrease in E/A ratio was more prominent in patients who were older than mean age of our study group which was 44 years (p<0.05). The post-therapy IRT was prolonged (94.0...