Increased thyroid hormones and autoantibodies levels associated with quasi-moyamoya disease

Abstract

Objectives: The purpose of this study was to investigate whether elevated thyroid autoantibodies associated with quasi-Moyamoya Disease (MMD). Methods: We retrospectively investigated angiographically defined patients with quasi-MMD patients. We compared clinical features, serum thyroid autoantibody values and T cell levels between quasi-MMD patients and control subjects. Results: A total of 103 patients with MMD and an equal number of healthy control subjects (n=103) were included. The prevalence of elevated thyroid autoantibodies (P=0.008) were significantly higher in patients with MMD than in control subjects. The increased thyroid hormone (OR, 11.03; 95% CI, 1.22 to 96.13; P=0.034) and Increased thyroid autoantibodies (OR, 6.38; 95% CI, 1.12 to 46.52; P=0.040) were significantly associated with increased risks of quasi-MMD, respectively. The antithyroid therapy can significantly attenuate disease progression than without special treatment in quasi-MMD patients with thyroid disease (P=0.041).