Abstract
Skin permeability in preterm infants was evaluated by observing the blanching response to topically applied 10 per cent Neo-Synephrine. The response consisted of speckles or islands of blanching which gradually coalesced to form a homogeneous pale area. Infants 28 to 34 weeks' gestational age had a rapid response lasting from 30 minutes to 6 to 8 hours. A response was no longer apparent by 21 days of postnatal life. Infants 35 to 37 weeks' responded less dramatically and had a longer lag period. Infants 38 to 42 weeks in most instances failed to exhibit blanching. Surface temperatures on strongly blanched and contiguous unblanched skin were identical. These data suggest immature barrier function in the epidermis of the preterm infant.
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