Abstract
BackgroundRecent studies implicate adipokines in the pathogenesis of inflammatory diseases, including psoriasis. In this study we evaluated the significance of serum resistin levels in psoriasis patients using a meta-analysis approach.223MethodsRelevant articles were retrieved by searching the following English and Chinese databases: Cochrane Library, PubMed, Springer Link, Chinese Biomedical Database (CBM) and Chinese National Knowledge Infrastructure (CNKI). The retrieved studies were subjected to a thorough screening procedure to identify case–control studies that contained the required data. Data was extracted from each study and Version 12.0 STATA statistical software was employed for statistical analyses.ResultsNine case–control studies, containing 421 psoriasis patients and 348 healthy controls, were included in this study. The major result of the meta-analysis revealed a statistically significant association between serum resistin levels and psoriasis (SMD = 2.22, 95%CI: 1.14-3.29, P < 0.001). Subgroup analysis based on ethnicity showed that, compared to the healthy controls, serum resistin levels were markedly higher in psoriasis patients in both Asian and Caucasian populations (Asians: SMD = 3.27, 95%CI = 1.62 ~ 4.91, P < 0.001; Caucasians: SMD = 0.91, 95%CI = 0.28 ~ 1.54, P < 0.001).ConclusionsBased on our results, we conclude that serum resistin level in psoriasis patients is higher than healthy controls, and raises the possibility that elevated serum resistin levels may be a novel diagnostic marker in psoriasis and may predict the occurrence of co-morbidities in psoriasis patients.
Highlights
Psoriasis is one of the most common chronic inflammatory skin diseases characterized by infiltration of T cells and hyper-proliferative keratinocytes [1,2]
It is possible that, in addition to the involvement of resistin in metabolic syndrome, resistin mediated increase in secretion of pro-inflammatory cytokines such as IL-6, IL-12 and tumor necrosis factor α (TNF-α), through activation of nuclear factor-B signal pathway, may directly effect the pathogenesis of psoriasis [19,20]. Consistent with this view, serum levels of resistin are positively associated with psoriasis severity, with higher serum resistin levels found in more advanced stages of psoriasis [21,22]
Subgroup analysis based on ethnicity revealed that serum resistin levels were significantly higher in psoriasis patients, compared to healthy controls, in both Asians and Caucasians (Asians: standardized mean difference (SMD) = 3.27, 95%confidence intervals (CI) = 1.62 ~ 4.91, P < 0.001; Caucasians: SMD = 0.91, 95%CI = 0.28 ~ 1.54, P < 0.001) (Figure 4A)
Summary
Psoriasis is one of the most common chronic inflammatory skin diseases characterized by infiltration of T cells and hyper-proliferative keratinocytes [1,2]. It is possible that, in addition to the involvement of resistin in metabolic syndrome, resistin mediated increase in secretion of pro-inflammatory cytokines such as IL-6, IL-12 and TNF-α, through activation of nuclear factor-B signal pathway, may directly effect the pathogenesis of psoriasis [19,20]. Consistent with this view, serum levels of resistin are positively associated with psoriasis severity, with higher serum resistin levels found in more advanced stages of psoriasis [21,22]. In this study we evaluated the significance of serum resistin levels in psoriasis patients using a meta-analysis approach.223
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
