Increased Serum Lipoprotein(a) Levels in Patients with Early Renal Failure

Abstract

Letters15 June 1999Increased Serum Lipoprotein(a) Levels in Patients with Early Renal FailureLeonardo A. Sechi, MD, Laura Zingaro, MD, and Ettore Bartoli, MDLeonardo A. Sechi, MDUniversity of Udine School of Medicine; 33100 Udine, Italy (Sechi)University of Udine School of Medicine; 33100 Udine, Italy (Zingaro)University of Udine School of Medicine; 33100 Udine, Italy (Bartoli)Search for more papers by this author, Laura Zingaro, MDUniversity of Udine School of Medicine; 33100 Udine, Italy (Sechi)University of Udine School of Medicine; 33100 Udine, Italy (Zingaro)University of Udine School of Medicine; 33100 Udine, Italy (Bartoli)Search for more papers by this author, and Ettore Bartoli, MDUniversity of Udine School of Medicine; 33100 Udine, Italy (Sechi)University of Udine School of Medicine; 33100 Udine, Italy (Zingaro)University of Udine School of Medicine; 33100 Udine, Italy (Bartoli)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-130-12-199906150-00026 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Both Elisaf and colleagues and Dr. De Lima report data that confirm elevation of serum Lp(a) levels in patients with early renal failure. Other groups have also reported similar data on patients with renal failure treated conservatively (1, 2). Elisaf and colleagues noted similar frequency distribution of apolipoprotein(a) isoforms in patients with normal and moderately impaired renal function. This finding is consistent with our observations. They also showed that serum Lp(a) levels are significantly increased only in the patients expressing the high-molecular-weight apolipoprotein(a) isoforms, whereas the patients expressing low-molecular-weight isoforms have Lp(a) levels similar to those in persons ...