Increased Serum Interleukin-10 Could lead to Allergic Disease Development in Helicobacter pylori Infected Adult

Abstract

Some research reported a protective effect of increased IL-10 in the development of allergic disease in children with H.pylori infection. Therefore this study aimed to investigate the possible protective effect of increased serum IL-10 levels and allergic disease symptoms in adult infected with H. pylori, furthermore we studied an association between ABO blood group with H. pylori infection. Methodes: Slide heamagglutination test was used to determine the blood group phenotype in 214 patients seropositiveH.pylori which they submitted to Azadi teaching hospital in Kirkuk city-Iraq for diagnosis and treatment, in addition serum levels of anti H. pylori antibody, IL-10, IL-4 and total IgE were assayed using ELISA kits for 70 patients, as well as for 20 healthy control. Results. The result showed significant increasing of the serum levels IL-10 and IL-4(P=0.000,0.003 respectively) and total IgE level (p=0.014) in H. pylori seropositive patients. Also the study showed higher incidence of H.pylori infection within O blood group of patients in compared with general population (p=0.000). Conclusion:H.pylori infection associated with increased IL-10 levels and IL-4 levels, and IL-4 production may responsible for the increase in serum IgE level and higher incidence of infection in O blood phenotype may considered as an etiological risk factor for the development of H. pylori infection.