Abstract
ObjectiveThe adipokine asprosin, which was recently discovered, facilitates hepatic glucose production. The aim of this study is to see whether serum asprosin concentrations are linked to diabetic nephropathy (DN).MethodsWe performed this investigation in a group of 212 type 2 diabetes (T2DM) patients. These patients were classified into three subgroups: DN0 group (normal to mildly increased), DN1 group (moderately increased), and DN2 group (severely increased) on the basis of urine albumin-to-creatinine ratio (ACR).ResultsWhen compared to the controls, T2DM patients had higher serum asprosin levels. The DN2 group had significantly higher serum asprosin than the DN0 and DN1 groups. Furthermore, the DN1 group had higher serum asprosin than the DN0 group. Serum asprosin was linked to a higher risk of T2DM and DN in a logistic regression analysis. Serum asprosin was found to be positively related with disease duration, systolic blood pressure, blood urea nitrogen, creatinine, uric acid, ACR, calcium channel blockers, and angiotensin-converting enzyme inhibitor/angiotensin II receptor blocker therapy, but negatively related with glomerular filtration rate, metformin, and acarbose therapy.ConclusionSerum asprosin increase with the progression of DN. Serum asprosin is correlated with renal function and ACR.
Highlights
Diabetes mellitus is becoming more common around the world [1]
Baseline parameter comparison Systolic blood pressure (SBP), HbA1c were higher, while high-density lipoprotein cholesterol (HDL-C) was lower in the case group compared to controls (Table 1)
The DN2 group had substantially higher SBP, blood urea nitrogen (BUN), creatinine (Cr), and uric acid (UA) as well as lower glomerular filtration rate (GFR) compared to DN1, DN0, and control groups (Table 1)
Summary
Diabetes mellitus is becoming more common around the world [1]. Diabetic nephropathy (DN), the most frequent diabetic complication, primarily caused the result of end-stage renal disease (ESRD) [2]. DN is responsible for 25–35 percent of type 2 diabetes mellitus (T2DM) cases and significantly raises T2DM patient mortality [3]. The underlying mechanism of DN is currently being investigated. The precise mechanism of DN is still uncertain [4]. Serum biomarkers, such as glycated albumin, copeptin, cystatin C, 8-hydroxy-2′-deoxyguanine
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
