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Abstract
BackgroundPrevious studies have disclosed that serum amyloid A (SAA) is likely involved in the lung cancer pathogenesis and progression. We performed a systematic evaluation and meta-analysis to disclose the correlation between the expression of SAA and lung cancer and to evaluate its value for lung cancer diagnosis.MethodsWe searched the relevant articles from the databases of Medline, Embase, Cochrance Library and Web of Science and calculated the standardized mean difference (SMD) with 95 % confidence interval (CI) to assess the expression difference of SAA between lung cancer and normal patients. Moreover, we counted the positive rate, sensitivity and specificity and drew a summary receiver operating characteristic curve (SROC) to evaluate the diagnostic value of SAA for lung cancer.ResultsA total of nine studies with 1392 individuals were included in this analysis. The results showed an increased SAA was correlated with the incidence of lung cancer (P < 0.001), especially with the lung squamous cell carcinoma (LSCC) (p = 0.012). The overall sensitivity and specificity of SAA for discerning lung cancer was 0.59 (95 % CI: 0.54–0.63) and 0.92 (95 % CI: 0.88–0.95), respectively. The area under the SROC curve was 0.9066 (SE = 0.0437).ConclusionsIncreased SAA in lung cancer was intimately correlated with the development and progression of lung cancer. A higher specificity of SAA suggested that it should be a significant biomarker for discerning lung cancer from normal individuals, especially for LSCC (p = 0.012).
Highlights
Previous studies have disclosed that serum amyloid A (SAA) is likely involved in the lung cancer pathogenesis and progression
Research shows that liver is mainly workplace for producing SAA protein which can stimulates the production of various cytokines, and SAA plays an important role in acute immune response [8]
Searching of literature Initially, a searching for the medical literature related to SAA and lung cancer identified 39 studies, and added two reports that were from the bibliographies of relevant articles
Summary
Previous studies have disclosed that serum amyloid A (SAA) is likely involved in the lung cancer pathogenesis and progression. Lung cancer has become the first cause of cancerassociated death in the world [1] This is a consistent opinion that early diagnosis and individualized therapy are conducive to improve the prognosis of lung cancer [2]. Many studies have demonstrated that abnormal protein expressions and gene mutations are correlated with the ontogenesis and progression of lung cancer [2], and reliable biomarkers derived from these abnormal molecules are more likely to help make the medical decision for individualized therapy [3]. Serum amyloid A (SAA), a kind of cytokine-induced, acute inflammatory response proteins, has been known to be likely involved in cancers [7].
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