Abstract
The present study was designed to investigate the influence of fasting on the ability of neurotensin (NT) to produce hypotension in anesthetized rats, to constrict the coronary vessels of perfused rat hearts and to stimulate isolated rat stomach strips and spontaneously beating atria of rats. The hypotensive effects of NT, in contrast to those elicited by bradykinin and isoproterenol, were markedly increased in 24h-fasted and 72h-fasted rats compared to control fed rats. The increase in perfusion pressure provoked by NT in perfused hearts derived from 24h-fasted and 72h-fasted rats was much larger than in hearts derived from control fed animals. On the other hand, the constrictor action of angiotensin in perfused rat hearts was not altered by fasting. The stimulatory effect of NT in stomach strips and atrial preparations derived from fasted rats was not increased when compared to tissues from control fed animals. It is suggested that prolonged period of fasting in rats may contribute to sensitize the cardiovascular system of these animals to the action of NT.
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