Abstract
The vagus nerve plays an essential role in homeostasis and inflammation. Clinically, peptic ulcer patients without helicobacter pylori (HP) infection may provide a population for studying the effect of vagal hyperactivity. There were interests in the association of gastrointestinal disease and urogenital disorders. Herein, we try to investigate subsequent risk of benign prostatic hyperplasia (BPH) in non-HP infected peptic ulcer patients. We identified 17,672 peptic ulcer admission male patients newly diagnosed in 1998–2007 from Taiwan Health Insurance Database, and 17,672 male comparison without peptic ulcer, frequency matched by age, and index-year. We assessed subsequent incidence of BPH in each cohort by the end of 2013, and then compared the risk of developing BPH between individuals with and without peptic ulcer. In addition, peptic ulcer patients underwent surgery were also examined. There were 2954 peptic ulcer patients and 2291 comparisons noted with the occurrence of BPH (25.35 and 16.70 per 1000 person-years, respectively). Compared to comparisons, peptic ulcer patients had a 1.45- and 1.26-fold BPH risk in multivariable Cox model and Fine and Gray model (95% CI 1.37–1.54 and 1.19–1.34). In age-stratified analysis, the highest risk of BPH was in 45–59 years (interaction p < 0.05). Regarding surgery types, peptic ulcer patients who underwent simple suture surgery (i.e.: with integrated vagus nerve) had a significant higher BPH risk than comparison (HR 1.50 and 95% CI 1.33–1.74; SHR 1.26 and 95% CI 1.07–1.48), while patients underwent truncal vagotomy/pyloroplasty showed a lower incidence of BPH. In this study, non-HP-infected male peptic ulcer patients were found to have an increased risk of subsequent BPH. Indicating that there might be a role of vagus nerve. Based on the limitations of retrospective nature, further studies are required.
Highlights
The vagus nerve plays an essential role in homeostasis and inflammation
There is an interest in the association between gastrointestinal diseases and urological diseases, studies focused on the impact of helicobacter pylori (HP) infection and urological diseases[16,17,18]
In age-stratified analysis, the highest risk of benign prostatic hyperplasia (BPH) was in 45–59 years (HR 1.73 and 1.63, 95% confidence interval (CI) 1.52–1.97 and 1.43–1.85 in multivariable Cox model and Fine and Gray model, respectively), and follow-up by 18–44 years, 60–74 years, and 75 + years (Table 2)
Summary
We collected 17,672 hospitalized males with peptic ulcer and 292,773 male comparisons without peptic ulcer history from LHID. Compared to the comparison cohort, peptic ulcer patients had a 1.45- and 1.26-fold BPH risk in multivariable Cox model and Fine and Gray model (95% CI 1.37–1.54 and 1.19–1.34), respectively, (Table 2). At the follow-up 16 years, the cumulative incidence of BPH in peptic ulcer patients without surgery and with surgery were higher than comparisons (23.24% and 32.81% vs 30.25%) (Fig. 2B). When compared to the comparison cohort, the peptic patients without surgery had a higher BPH risk (HR 1.46 and 95% CI 1.38–1.55; SHR 1.26 and 95% CI 1.19–1.34), followed by those with surgery (HR 1.39 and 95% CI 1.24–1.57; SHR 1.24 and 95% CI 1.10–1.40) (Table 3). Among different peptic ulcer associated-surgery, patients with simple suture had a significant higher BPH risk when compared to comparisons (HR 1.50 and 95% CI 1.33–1.70; SHR 1.33 and 95% CI 1.17–1.51). Patients underwent TVP and other surgery were with a lower incidence of BPH, but without significance
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