Increased risk of stroke among hypertensive patients with abnormally short sleep duration: analysis of the national health interview survey

Abstract

acute myocardial infarction .This study aimed to investigate the association between MMP-9 and TIMP-1 levels and the occurrence of LVH in resistant hypertensive patients (RHTN) and mild to moderate hypertensives (HTN). Methods:We measured plasma TIMP-1 and MMP-9 (ELISA) in 126 HTN subjects and 86 RHTN patients. LVH was analyzed by left ventricle (LV) mass index (LVMI). Measurements of the dimensions of the LV were performed using the American Society of Echocardiography recommendations. The Mann-whitney test was used to compare the levels of biomarkers of extracellular matrix and IMVE between the groups while Spearman’s correlation was used to determine the relationship between the variables. Results: Resistant hypertensive patients had higher prevalence of HVE (66%) compared to mild to moderate hypertensive (46%), p1⁄40.005. Higher levels of TIMP-1 (mean SD) were found in RHTN (93.75 29.09 pg/mL) compared with HTN individuals (86.24 27.53 pg/mL) while lower MMP-9/TIMP-1 relationship was observed in RHTN group (0.37 0.5 vs. 0.77 1.75, p1⁄40.015). No differences were found between MMP-9 levels between the groups. TIMP1 levels were inversely correlated with LVMI in RHTN group (r1⁄4 -0.31 p1⁄40.005). Conclusion: RHTN patients had higher prevalence of LVH and higher TIMP-1 plasma levels. Moreover, RHTN group presented lower MMP-9/ TIMP-1 ratio compared to HTN. These data suggest that changes in the MMP-9/TIMP-1 balance may play an important role in the structural and clinical manifestations of resistant hypertension.