Abstract
BackgroundProspective data on the association between ischemic stroke and ankylosing spondylitis (AS) in the young are sparse. The purpose of this population-based, age- and sex-matched longitudinal follow-up study was to investigate the risk of developing ischemic stroke in young patients with AS.MethodsA total of 4562 patients aged 18- to 45-year-old with at least two ambulatory visits in 2001 with a principal diagnosis of AS were enrolled in the AS group. The non-AS group consisted of 22810 age- and sex-matched, randomly sampled subjects without AS. The two-year ischemic stroke-free survival rate for each group were calculated using the Kaplan-Meier method. Cox proportional hazards regression analysis was used to estimate the hazard ratio of ischemic stroke after adjusting for demographic and clinical covariates.ResultsDuring follow-up, 21 patients in the AS group and 53 in the non-AS group developed ischemic stroke. The ischemic stroke-free survival rate over the 2 year follow-up was lower in the AS group than the non-AS group (p = 0.0021). The crude hazard ratio of ischemic stroke for the AS group was 1.98 (95% CI, 1.20–3.29; p = 0.0079) and the adjusted hazard ratio after controlling for demographic and comorbid medical disorders was 1.93 (95% CI, 1.16–3.20; p = 0.0110).ConclusionOur study showed an increased risk of developing ischemic stroke in young patients with AS.
Highlights
Ankylosing spondylitis (AS), an autoimmune disease with systemic inflammation, predominantly involves the axial skeleton [1]
ankylosing spondylitis (AS) has been associated with an increased risk of ischemic heart disease [2,3,4,5,6,7,8], but whether AS patients are at a higher risk of ischemic stroke remains controversial
The aim of this population-based, age- and sexmatched longitudinal follow-up study was to evaluate the risk of developing ischemic stroke in young patients with AS
Summary
Ankylosing spondylitis (AS), an autoimmune disease with systemic inflammation, predominantly involves the axial skeleton [1]. Two of these studies were based on a crosssectional survey [9,11] and prospective data on the relationship between AS and cerebrovascular diseases are sparse These studies were carried out mainly on middle-aged or older AS patients, and little is known about cerebrovascular risk in young AS patients. The aim of this population-based, age- and sexmatched longitudinal follow-up study was to evaluate the risk of developing ischemic stroke in young patients with AS. Prospective data on the association between ischemic stroke and ankylosing spondylitis (AS) in the young are sparse The purpose of this population-based, age- and sex-matched longitudinal follow-up study was to investigate the risk of developing ischemic stroke in young patients with AS
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